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The Globe and Mail A +6 The subject who is truly loyal to the Chief Magistrate will neither advise nor submit to arbitrary measures.close panel DARRYL DYCK/The Globe and Mail DAINA LAWRENCE Published November 26, 2014 Updated March 25, 2017 A series looking at the unique challenges facing Canada's midmarket companies and how they innovate, stay competitive and grow.

This piece looks at the risky biotech sector, where Canadian mid-sized businesses are attractive to larger corporations, which are able to bring products across the finish line For example, according to the industry report Healing, Fueling, Feeding: How Biotechnology Is Enriching Your Life, the US spends approximately $2 billion annually   May 6, 2018 | Eleven Biotherapeutics, Vivus, Trevena, Aralez Pharmaceuticals and Pluristem Therapeutics were last week's top gainers on the NASDAQ..This piece looks at the risky biotech sector, where Canadian mid-sized businesses are attractive to larger corporations, which are able to bring products across the finish line.

But they have to grow big enough to be enticing.7, 2012, Robert Heft sold his biotechnology company, Montreal-based Enobia, to U 26 Nov 2014 - 7, 2012, Robert Heft sold his biotechnology company, Montreal-based Enobia, to U.S. pharmaceutical giant Alexion Pharmaceuticals Inc. for the robust price    In Canada, you get to a point where it requires too much capital and too much infrastructure for you to actually do it on your own,  explains Andrew  .7, 2012, Robert Heft sold his biotechnology company, Montreal-based Enobia, to U.pharmaceutical giant Alexion Pharmaceuticals Inc.) – the largest sale of a private, precommercial biopharmaceutical company, according to industry experts.

Heft and his colleagues achieved a rarity in the industry.They had attracted the attention of Big Pharma and cashed in.Story continues below advertisement Biotech can involve long timelines, be capital intensive and experience high business failure rates.Some investors and larger companies seek safety in size, making Canada's mid-sized biotech companies an attractive market – as long as they can mitigate their risk, secure investors and reach the first stages of commercialization.

A tough decision The struggle over the decision to sell is evident in Dr.On the one hand, wanting to finish what we started and put so much into, on the other hand, wanting to deliver to our shareholders." But like many Canadian biotech companies, Enobia needed the funds and connections of a larger corporation to bring its product across the finish line.

It was Enobia's lead therapy, asfotase alfa, a treatment for the life-threatening bone disease hypophosphatasia, that sealed the deal with Alexion.

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The therapy was more than six years in the making and became the company's primary focus after Dr.Heft took over as Enobia's president in late 2005.Enobia used more than $150-million to gather preclinical data on asfotase alfa and wanted to bring this treatment to patients suffering from this disease 27 Feb 2012 - Published February 27, 2012 Updated 6 hours ago. As a Canadian in Silicon Valley, venture capitalist Ann Hanham has done it all. Her distinguished résumé includes taking the first stem cell device for approval to the Food and Drug Administration, as well as taking public a number of companies. But after  .Enobia used more than $150-million to gather preclinical data on asfotase alfa and wanted to bring this treatment to patients suffering from this disease.

Today, Alexion has brought the drug through its Phase 2 clinical trials.

"In Canada, you get to a point where it requires too much capital and too much infrastructure for you to actually do it on your own," explains Andrew Casey, president and chief executive officer of national industry association BIOTECanada Venture capitalist targets biotech sector The Globe and Mail."In Canada, you get to a point where it requires too much capital and too much infrastructure for you to actually do it on your own," explains Andrew Casey, president and chief executive officer of national industry association BIOTECanada."You have to license it out or sell it to a larger company Venture capitalist targets biotech sector The Globe and Mail."You have to license it out or sell it to a larger company." Life sciences and GDP Story continues below advertisement Canada's life sciences biotechnology sector is a significant part of the economy.5-billion worth of goods manufactured in Canada, and contributed almost $4.

6-billion to Canada's gross domestic product in 2012, according to Statistics Canada.But they need to make it to the commercialization stage first – something many struggle to achieve.So how do some companies make it from risky startup to the goal of attractive mid-sized company? There are ways to shield oneself from some of the risk, and it requires capital, something the biotech industry has struggled for since 2008, explains Mr.Unlike other sectors, such as mining or oil and gas, biotech companies are generally developing their product with the hope of attracting attention from potential partners or buyers.

"And this is where the challenge comes in," Mr."On the surface you go, well that's too bad because that's a Canadian company that's been lost now," he says, but he explains that this is how many biotechnologies come to market, due to a shift in R&D from the larger companies.These larger companies don't develop in-house, rather they find the next company to invest in and conferences are a place where many Canadian firms get noticed, he says.

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Speed dating for industry giants Story continues below advertisement He likens the process to speed dating for many of these mid-sized companies that only have a limited amount of time to present ideas and court the attentions of industry giants.

"You look around the floor and you've got all those multinationals: Pfizer and Novartis, Roche," describes Mr.Casey, "and they're essentially trying to find the diamond in the rough most, if not all, biotech companies would be unable to stay in business. As with previous waves of technological advancement, patents are fundamental to the industry and often are contested by competitors. Financing. According to survey results published by the U.S. Department of Commerce, 53 percent of firms reported  .Casey, "and they're essentially trying to find the diamond in the rough.

" And these mid-sized companies want to be noticed by other companies or by equity investors, such as B.-based companies Xenon Pharmaceuticals Inc.

And after investors get involved? "Then all of a sudden you're no longer living out of the back of your car and that allows you to put in place the business structure, pay people, pay clients, do more scientific research, undertake some more clinical studies," Mr."It allows you to really start to run the company jreference.com/report/where-to-purchase-a-biotechnology-report-senior-12-hours-chicago-100-plagiarism-free."It allows you to really start to run the company." The struggle to grow The struggle to even get to the mid-market level is not insignificant, either.

Researchers and industry experts, such as Mr.Casey, argue that there needs to be more funding and facilities provided to usher products from the research level to the commercialization stage.For example, the Centre for Drug Research and Development, with headquarters located at the University of British Columbia, and Montreal's Inception Sciences Inc., act as incubators to stave off risk at these first delicate stages of innovation.Aziz Ghahary, a UBC professor, and PhD candidate Ryan Hartwell wouldn't even be sitting in their lab if it wasn't for outside funding from several supporters, including WorkSafeBC and the Canadian Institutes of Health Research, and a lab facility supplied by Vancouver Coastal Health and the UBC department of medicine.They have developed a topical burn treatment cream, called FibroStop, and they have attracted attention from Calgary-based mid-sized company Advanced Orthomolecular Research (AOR), set to work with UBC to manufacture the cream for the Phase 1 study.These researchers act as part of the biotech pipeline needed to foster companies 20 times their size and add products to their portfolios.

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Looking for a larger company "We purposely didn't license it out because we wanted to advance the technology to be presentable to a larger company," Dr.

The sheer cost of overhead for this research would have kept this product from being developed and supplied to AOR."Without the financial and academic support we received, we couldn't have achieved where we are today," Mr Biotechnology professionals enjoy an active lifestyle in Vancouver, Canada.   Bike friendly paths line the city, golf can be enjoyed all year round and skiing is only a 30 minute drive from downtown Vancouver.   In a recent report by JLL, Vancouver was named to the report's Global Watch List: 10 Cities in the Spotlight.."Without the financial and academic support we received, we couldn't have achieved where we are today," Mr.

Heft, retirement from the biotech industry was a consideration after the Enobia sale was completed.

"I did give it a lot of thought," he admits.Instead, he now sits on the board of several smaller biotech firms with the hopes of building the industry he's been involved with for almost three decades.The Globe and Mail A +6 The subject who is truly loyal to the Chief Magistrate will neither advise nor submit to arbitrary measures .The Globe and Mail A +6 The subject who is truly loyal to the Chief Magistrate will neither advise nor submit to arbitrary measures.close panel Kim White for The Globe and Mail/kim white The Globe and Mail Updated May 3, 2018 As a Canadian in Silicon Valley, venture capitalist Ann Hanham has done it all.Her distinguished r sum includes taking the first stem cell device for approval to the Food and Drug Administration, as well as taking public a number of companies.

But after being away for over two decades, Ms.Hanham is coming home – not because the venture capital business in Canada is thriving, but because it isn't."It is heartbreaking that so much talent and so much brilliant research isn't being commercialized," says Ms.Hanham from San Francisco, where she is currently a managing director at Burrill & Company, a venerable venture capital firm that invests money on behalf of partners such as Unilever NV, Archer- Daniels-Midland Co.

Story continues below advertisement The numbers tell a grim story.In 2000, the height of venture capital activity in this country, $5.

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9-billion was invested in 1,007 Canadian startups, according to Thomson Reuters.5-billion was raised by 444 Canadian firms.Hanham is putting her Silicon Valley contacts and experience to work 19 Apr 2018 - It's unclear whether a deepening trade rift with the US could slow the stream of cash from China to medical innovation hubs such as Silicon Valley and Cambridge, Massachusetts..Hanham is putting her Silicon Valley contacts and experience to work.

Her goal: assemble a $200-million biotechnology and life sciences fund that invests in both stellar university research as well as burgeoning companies in industrial chemicals, agricultural biotechnology, life sciences and biofuels that need capital.She is moving back to the country to run it.

For her, this endeavour isn't about the money to be made.It's about rescuing all the Canadian research that is created, only to die.Canada's spending on science research and development, per capita, is in the top tier globally – a recent report pegged federal R&D spending at $7-billion, largely through tax credits – but its return on those investments is practically negligible jreference.com/essay/..Canada's spending on science research and development, per capita, is in the top tier globally – a recent report pegged federal R&D spending at $7-billion, largely through tax credits – but its return on those investments is practically negligible.Our universities have some of the brightest minds around, but very little of their work sees the light of day."It's so obvious when you go to Toronto or other Canadian places that there's way more technology than there is money to fund it," said Mike Powell, general partner at venture capital firm Sofinnova Ventures in Silicon Valley.

Originally from Toronto and armed with a PhD in physical chemistry from the University of Toronto, he now lives in California and keeps up with what's happening back home.Governments and angel investors – typically wealthy individuals who invest in startups – fund a lot of early-stage research that typically results in prototypes.But as soon as a Canadian biotech company needs more than $10-million to grow, there is almost no way to get it from domestic sources.Typically, successful small biotechnology companies that receive venture capital funding ultimately go public, allowing their private backers to exit, or they get sold to a pharmaceutical behemoth or other corporate buyers, such as Monsanto Co.In these markets, IPOs are hard to swing even for larger, more established companies, and corporations won't spend wildly because of economic constraints.

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That means early backers have trouble cashing in profits.Story continues below advertisement Story continues below advertisement Because so many potential sources of money have vacated the field, the Ontario government has flirted with proposing a venture capital tax credit of up to 35 per cent.Investors must take big risks to get involved in startups, and to date few have been willing With a successful hire, you'll receive a bevy of competitive benefits including paid time off, medical and vision coverage, a 401(k) plus match, disability  Sponsored - 6 hours ago - save job. Medical Specialist, Immunology - Portland, OR · Regeneron - 125 reviews - Portland, OR. The Medical Specialist, Respiratory (MS) will  .Investors must take big risks to get involved in startups, and to date few have been willing.

From afar, the easy answer is asking Canada's behemoth pension funds to step up.

But in 2001 the federal government changed its rules and allowed these funds to hold a greater percentage of foreign investments.With the whole world to invest in, there's less reason for them to put money into small Canadian upstarts.Life sciences and biotech are at a particular disadvantage.Other tech startups, like mobile phone app developers, have a lot of media hype around them right now, and their products are also easier for an investor to understand than, say, a new molecule used to treat pancreatic cancer.Science research also requires more funding over a longer period of time.

On average, a life sciences startup will need $100-million to $120-million before it develops its product enough to be sold or go public.Nick Galakatos, managing partner at Clarus Ventures in Cambridge, Mass., says life science venture capital investors are more timid in this environment.These days, they require a startup to be further along in its development before they offer up some cash.

Rather than invest on a bold idea, they might look for products that have already been tested on dozens of patients.

Yet studies that have shown that investing in life sciences and biotech can actually yield better returns than other forms of technology.

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A study by Bruce Booth and Bijan Salehizadeh published in the science journal Nature America found that from 2000 to 2010, health care venture investing yielded an average return of 15 per cent for investors who have sold their shares, substantially more than the technology venture sector.Hanham thinks Canadian firms can show that kind of growth, as long as they are taught to think about marketing across borders."Every company that this fund will invest in will go global from day one," she says Write my report biotechnology Harvard Graduate 25 pages / 6875 words A4 (British/European).

"Every company that this fund will invest in will go global from day one," she says.

firms now have to do the same, something they aren't used to.Because North America was the historical leader in development, the continent's life sciences startups don't think to look for competition outside their borders Biotech financing EY.Because North America was the historical leader in development, the continent's life sciences startups don't think to look for competition outside their borders.Recently, a Canadian firm approached Ms Biotech financing EY.

Recently, a Canadian firm approached Ms.

Hanham with a solid business plan, and she replied: "Well, this is great, but do you know there's a company in Singapore that's two years ahead of you?" "I spend a lot of time in Asia, and I can tell you, they're going to eat our lunch if we don't get moving," she says.Follow Tim Kiladze on Twitter @timkiladze Attracting Innovators to the World’s Best Place to Live Nestled in southwest British Columbia, Canada, and surrounded by majestic mountains, mature forests and miles of beaches, it’s no wonder Vancouver is attracting the next generation of innovators and is often touted as one of the world’s best places to live.Vancouver’s year-round moderate climate lends to an active lifestyle where cycling to work is commonplace.Bike friendly paths line the city, golf can be enjoyed all year round and skiing is only a 30 minute drive from downtown Vancouver.Qu’s offices and laboratory are on one of the city’s many bike paths and are a short walk from bus stops and SkyTrain, the city’s light rail system.

Recognized as a clean and safe city, Vancouver attracts an estimated nine million visitors a year.First-rate community centres are accessible from all parts of the city, a legacy that followed hosting the 2010 Winter Olympics.In addition to the local skiing offered, some of the best skiing at Whistler Mountain Resort is a two hour drive north of Vancouver.Neighbouring city Seattle in the United States is only a 2.

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The population of Vancouver and its surrounding area is nearly 2.Transportation in the region includes buses, a light rail system (SkyTrain) and short distance passenger ferries (SeaBus).A collaboration of scientific talent Commercial success in the life sciences community in British Columbia can be attributed to the strong collaborative approach amongst the universities, research agencies, government and industry 3 Apr 2018 - With close to half of the total US Food and Drug Administration (FDA) approved products in 2017 from biotech companies—20 more than 2016—this year may hold more approvals than ever before. A 2018 market report from Deloitte on the entire life science sector indicated a projection of $8.7 trillion by the  .A collaboration of scientific talent Commercial success in the life sciences community in British Columbia can be attributed to the strong collaborative approach amongst the universities, research agencies, government and industry.

Federal and provincial government grants help to support early-stage scientific innovation.

The University of British Columbia boasts top-tier research which has spurred many new technologies for development and the spin-off of more than 125 new life science companies Chinese funds pour US 1 4b into US biotechnology firms in the first nbsp.The University of British Columbia boasts top-tier research which has spurred many new technologies for development and the spin-off of more than 125 new life science companies.Vancouver is also recognized as one of the top life sciences clusters globally.In a recent report by JLL, Vancouver was named to the report’s Global Watch List: 10 Cities in the Spotlight.Stanley Park is a natural rainforest in the heart of Vancouver Vancouver is home to Stanley Park, a 1,001-acre natural rainforest in Downtown Vancouver, which attracts 8 million visitors a year and was recently named the “Top Park in the World” by TripAdvisor.A 10 kilometre seawall wraps around the park giving visitors some of the best views of the city.

Vancouver is home to culturally diverse dining Foodies love the culinary diversity offered in Vancouver.As a Pacific Rim city, fresh seafood and Asian-inspired dishes make up a westcoast menu.A multicultural city, Vancouver is a mecca of food stops – there’s something for everyone.